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Agnes DOBOS

Supervisor:

Aleksandr Ovsianikov

Bio:

Agnes earned her BSc in Biochemical Engineering at the Technical University of Budapest in 2014. She continued her studies in Sweden and Austria, and received MSc double degree in Tissue Engineering and Medical Biosciences at FH Wien and the University of Linköping in 2016. Her research interests lie in the area of biomaterials, therefore she joined BIOINTERFACE as a PhD student under the supervision of Dr. Aleksandr Ovsianikov.

Contact:

EMail: agnes.dobos@tuwien.ac.at

Tel: +43 (1) 58801 30837

PhD project:

Her PhD project revolves around biomimetic in vitro tissue models. It combines multiphoton processing, a cutting edge 3D printing method, with cell biology in order to mimic the natural cell microenvironment. By using this novel approach she would not only be able to better understand the impact of the extracellular matrix on cell behavior, but also to fabricate devices for testing purposes. This way she could model diseases, test pharmaceutical products and substances, while reducing the ethically questionable and expensive preclinical animal tests.

Research key words:

multiphoton proccessing, 3D in vitro models, cell biology, biomaterials

Conference contributions:

  • Talk "High resolution 3D printing, Hydrogels, and Biofabrication" , Austrian Cluster of Tissue Regeneration Annual meeting, Vienna, Austria, 2019
  • Talk "High resolution 3D printing, Hydrogels, and Biofabrication" Portuguese Association for Biofabrication , Porto, Portugal, 2018
  • Poster Presentation "Laser-based 3D printing of hydrogels: a versatile approach for accurate 3D cellular models", TERMIS, Tokyo, Japan, 2018
  • Talk "On-Chip Two-Photon Polymerization of Vascular Structures" ISBF, Wurzburg, Germany, 2018
  • Talk " Screening of Two-Photon Activated Photodynamic Therapy Sensitizers Using 3D Cancer Models" BSTE, Ghent, Belgium, 2018
  • Talk "High-resolution 3D printing of biomimetic microenvironments to study T-cell activation", Wilhelm und Else Heraeus-Seminar: Micro-and Nanostructured Biointerfaces, Bad Honnef, Germany, 2018
  • Poster presentationat the Danube Vltava Sava Polymer Meeting (DVSPM) 2017, Sept 5th-8th, Vienna, Austria; "Comparison of the Effect of Photoinitiator P2CK and AS7 on the Viability of Encapsulated Human Adipose-Derived Stem Cells via Two-Photon Polymerization"

Publications:

  • A. Dobos, W. Steiger, D. Theiner, P. Gruber, M. Lunzer, J. Van Hoorick, S. Van Vlierberghe, A. Ovsianikov, "Screening of two-photon activated photodynamic therapy sensitizers using a 3D osteosarcoma model,"Analyst 2019, DOI 10.1039/C9AN00068B.
  • M. Tromayer*, A. Dobos*, P. Gruber, A. Ajami, R. Dedic, A. Ovsianikov, R. Liska, "A biocompatible diazosulfonate initiator for direct encapsulation of human stem cells via two-photon polymerization," Polym. Chem. 2018, 9, 3108. DOI: 10.1039/c8py00278a, * equal contribution
  • B. Peter, J. Nador, K. Juhasz, A. Dobos, L. Korosi, I. Székács, D. Patko, R. Horvath,​ "Incubator proof miniaturized Holomonitor to in situ monitor cancer cells exposed to green tea polyphenol and preosteoblast cells adhering on nanostructured titanate surfaces: validity of the measured parameters and their corrections," J. Biomed. Opt. 2015, 20, 067002.DOI 10.1117/1.JBO.20.6.067002

  • A. Dobos, J. Van Hoorick, W. Steiger, P. Gruber, M. Markovic, O. G. Andriotis, A. Rohatschek , P. Dubruel, P. J. Thurner, S. Van Vlierberghe, S. Baudis, A. Ovsianikov "Thiol-Gelatin-Norbornene Bioink for Laser‐Based High‐Definition Bioprinting" Advanced Healthcare Materials 2019, DOI: doi.org/10.1002/adhm.201900752

  • J. Van Hoorick, L. Tytgat, A. Dobos, H. Ottevaere, J. Van Erps, H. Thienpont, A. Ovsianikov, P. Dubruel, S. Van Vlierberghe "(Photo-)crosslinkable Gelatin Derivatives for Biofabrication Applications" Acta Biomaterialia 2019 DOI: doi.org/10.1016/j.actbio.2019.07.035